Publications

論文

2025

査読付き論文

Marginal-zone B cells as promising targets of an mRNA-loaded, lipid-nanoparticle cancer vaccine

  • Yuichi Suzuki, Mai Yakuwa, Mina Sato, Eleni Samaridou, Moritz Beck-Broichsitter, Masatoshi Maeki, Manabu Tokeshi, Yuma Yamada, Hideyoshi Harashima, Yusuke Sato
  • Next Nanotechnology, 8, 100154 (2025)
    https://doi.org/10.1016/j.nxnano.2025.100154

Microfluidic technologies for protein crystallography: advances and applications

  • Masatoshi Maeki, Akihiko Ishida, Manabu Tokeshi
  • Anal. Sci., 41, 1203-1211 (2025)
    https://doi.org/10.1007/s44211-025-00767-z

Splenic B cell-targeting lipid nanoparticles for safe and effective mRNA vaccine delivery

  • Yuichi Suzuki, Mai Yakuwa, Mina Sato, Eleni Samaridou, Moritz Beck-Broichsitter, Masatoshi Maeki, Manabu Tokeshi, Yuma Yamada, Hideyoshi Harashima, Yusuke Sato
  • J. Control. Release, 382, 113687 (2025)
    https://doi.org/10.1016/j.jconrel.2025.113687

Paper discs in a 3D printed microplate hybrid microfluidic device for low-cost, rapid, and ultrasensitive paper-based bioluminescence detection of human epidermal growth factor receptor 2 (HER2) breast cancer biomarker

  • Ahmed A. Shalaby, Asmaa Salah, Akihiko Ishida, Masatoshi Maeki, Manabu Tokeshi
  • Biosens. Bioelectron.:X, 24, 100621 (2025)
    https://doi.org/10.1016/j.biosx.2025.100621

Unraveling the Molecular Mechanism of Transient Multilamellar Formation in Ethanol-Modified Vesicle Solutions

  • Kana Shibata, Masatoshi Maeki, Manabu Tokeshi, Wataru Shinoda
  • Langmuir, 41, 13372–13380 (2025)
    https://doi.org/10.1021/acs.langmuir.5c01139

Lipid nanoparticle delivery of the CRISPR/Cas9 system directly into the mitochondria of cells carrying m.7778G>T mutation in MtDNA (mt-Atp8)

  • Kaede Norota, Sen Ishizuka, Misa Hirose, Yusuke Sato, Masatoshi Maeki, Manabu Tokeshi, Saleh M. Ibrahim, Hideyoshi Harashima, Yuma Yamada
  • Sci. Rep., 15, 18717 (2025)
    https://doi.org/10.1038/s41598-025-03671-8

Microfluidic Production of Exosome-Mimicking Lipid Nanoparticles for Enhanced RNA Delivery: Role of Exosomal Proteins

  • Masatoshi Maeki, Ayuka Niwa, Shota Oyama, Kyoko Aratani, Rina Ito, Yuichi Suzuki, Yusuke Sato, Akihiko Ishida, Hideyoshi Harashima, Manabu Tokeshi
  • ACS Appl. Mater. Interfaces, 17, 41666–41679 (2025)
    https://doi.org/10.1021/acsami.5c06927

Examining the Impact of Storage Conditions on the Stability of a Liquid Formulation of mRNA-Loaded Lipid Nanoparticles

  • Mina Sato, Eleni Samaridou, Moritz Beck-Broichsitter, Masatoshi Maeki, Shunsuke Kita, Manabu Tokeshi, Katsumi Maenaka, Hideyoshi Harashima, Yusuke Sato
  • Pharmaceutics, 17, 1194 (2025)
    https://doi.org/10.3390/pharmaceutics17091194

Noncompetitive Fluorescence Polarization Aptamer Assay for Detecting SARS-CoV-2 Variants

  • Chang Yu-Ting, Rigel Suzuki, Yoichiro Fujioka, Akihiko Ishida, Ayuko Imai, Mao Fukuyama, Motohiro Kasuya, Yusuke Ohba, Takasuke Fukuhara, Koji Shigemura, Akihide Hibara, Masatoshi Maeki, Manabu Tokeshi
  • ACS Omega, 10, 51228–51235 (2025)
    https://doi.org/10.1021/acsomega.5c06304

Programmable Antigen-Specific Immunity via Self-Adjuvanting Nanovaccines Co-Delivering Immune Modulators

  • Keita Ito, Yoshiyuki Manabe, Shino Ohshima, Masatoshi Maeki, Manabu Tokeshi, Hiroshi Inaba, Kazunori Matsuura, Kazuya Kabayama, Yoshie Kametani, Koichi Fukase
  • Angew. Chem. Int. Ed., e20474 (2025)
    https://doi.org/10.1002/anie.202520474

The effect of guide RNA thermal denaturation on the quality of Cas9 ribonucleoprotein-loaded lipid nanoparticle formulations

  • Rina Shimizu, Yuji Kashiwakura, Morisada Hayakawa, Shunsuke Kita, Mina Sato, Masatoshi Maeki, Manabu Tokeshi, Katsumi Maenaka, Tsukasa Ohmori, Yuma Yamada, Hideyoshi Harashima, Yusuke Sato
  • RSC Pharm., 3, 77-87 (2026)
    https://doi.org/10.1039/D5PM00189G

CRISPR-Cas3-based editing for targeted deletions in a mouse model of transthyretin amyloidosis

  • Saeko Ishida, Yusuke Sato, Keisuke Chosa, Eri Ezawa, Yuko Yamauchi, Masaaki Oyama, Hiroko Kozuka-Hata, Rina Ito, Rikako Sato, Masatoshi Maeki, Tomo-o Ishikawa, Kenichi Yamamura, Kohei Takeshita, Kensuke Yamaguchi, Yuta Kochi, Fumitaka Hashiya, Yiwei Liu, Naoko Abe, Hiroshi Abe, Yoshiki Sekijima, Kazuto Yoshimi, Tomoji Mashimo
  • Nat Biotechnol (2026)
    https://doi.org/10.1038/s41587-025-02949-6